Scope:
Program for Advanced Medical Education
(Doctoral program for physicians)
Subject:
Graduate course - Structural Biology
Dates:
10-14 October
Place:
IGC - Theano Auditorium (below the library)
Faculty
Organized by Alekos Athanasiadis and José Pereira-Leal
Schedule (still subject to many changes)
Monday
09:30 - 09:50 - Welcome
10:00 – 12:00 - Introduction to Structural Biology (Alekos) - Joint with PIBS
14:00 - 16:00 - Introduction to Structural Biology -Cont (JPL)
Tuesday
10:00 - 12:00 -Principles of Protein Crystallography (Montoya) - Joint with PIBS
12:00 - 13:00 - IGC seminar
14:00 - 16:00 - The mammalian chaperonin CCT in complex with tubulin (Montoya) - Joint with PIBS
16:00 - 18:00 - Structural Visualisation Practical (Bruno)
Wednesday
15:00 - 17:00 - Journal Clubs
Thursday
10:00 – 12:00 - ”Polynucleotide cytosine deaminase evolution and function in vertebrates: AID, APOBEC1, and the APOBEC3s” (Harris) - Joint with PIBS
14:00 - 16:00 - “Structure-function studies of human APOBEC3G and novel strategies to combat HIV/AIDS” (Harris) - Joint with PIBS
Friday
10:00 - 12:00 - “Zalpha domains in foreign nucleic acids recognition” (Alekos) - Joint with PIBS
12:00 - 13:00 - IGC seminar HIV Vif hijacks multiple cellular proteins to counteract APOBEC3G and promote pathogenesis (Harris)
Journal Club
(30 min presentation + discussion per group)
1. Kumar P, Henikoff S, Ng PC: Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm. Nat Protoc 2009, 4:1073–1081.
2. Wu CC, Li TK, Farh L, Lin LY, Lin TS, Yu YJ, Yen TJ, Chiang CW, Chan NL: Structural Basis of Type II Topoisomerase Inhibition by the Anticancer Drug Etoposide. Science 2011, 333:459–462.
3. Lee et al. Comprehensive analysis of missense variations in the BRCT domain of BRCA1 by structural and functional assays. Cancer Research (2010) vol. 70 (12) pp. 4880-90