Scope:

Program for Advanced Medical Education

(Doctoral program for physicians)

Subject:

Graduate course - Structural Biology

Dates:

18-22 October

Place:

IGC - Theano Auditorium (below the library)

Faculty:

Guillermo Montoya - CNIO - ES

Francisco Enguita - IMM - PT

Claudio Gomes - ITQB - PT

Nuno Palma  -BIAL - PT

Alekos Athanasiadis - IGC - PT

Maria Luisa Rodrigues - Instituto Gulbenkian de Ciência - PT

Bruno Victor - ITQB

Jose Pereira-Leal- Instituto Gulbenkian de Ciência - PT 

 

Schedule:

Monday

10:30 - 12:30 - Protein Structure - Francisco Enguita

14:00 - 15:30 - Protein evolution - Jose Pereira-Leal

16:00 - tba

Tuesday

09:30 - 10:30 - RNA Structure - Francisco Enguita

10:30 - 11:30 - Tools and databases - Jose Pereira-Leal

12:00 - 13:00 - IGC seminar

14:00 - 17:00 - Visualisation Practical

Wednesday

09:30 - 10:15 - Basic principles of protein Folding and structure - Claudio Gomes

10:30 - 11:00 - Protein Folding in the Cell - Claudio Gomes

11:15 - 12:00 - Diseases of protein folding: Protein misfolding, aggregation and amyloids - Claudio Gomes

12:15 - 13:00 - Research Seminar: highlights from the lab - Claudio Gomes

14:30 - 17:30 - JOURNAL CLUB (with JPL, FE, AA)

Thursday

10:00 - 12:00 - On the recognition of foreign nucleic acids by innate immunity - Alekos Athanasiadis

14:00 - 16:00 - Methods to study protein structures - Guillermo Montoya

17:00 - 18:30 - Meeting with António Coutinho

Friday

10:00 - 12:00 - Homing endonucleases: from basics to therapeutic applications - Guillermo Montoya

12:00 - 13:00 - IGC seminar

14:00 - 16:00 - in-silico strategies in drug design - Nuno Palma

16:00 - 17:00 - PROJECT 

17:00 - Beer in the rain

Journal club papers:

(30 min presentation + discussion per group)

 

Dunkle, J.A., Xiong, L., Mankin, A.S. and Cate, J.H. Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyltransferase center explain spectra of drug action. Proc Natl Acad Sci U S A.

Yamasaki, M., Li, W., Johnson, D.J. and Huntington, J.A. (2008) Crystal structure of a stable dimer reveals the molecular basis of serpin polymerization. Nature, 455, 1255-1258.

Lee et al. Comprehensive analysis of missense variations in the BRCT domain of BRCA1 by structural and functional assays. Cancer Research (2010) vol. 70 (12) pp. 4880-90

Cígler et al. From nonpeptide toward noncarbon protease inhibitors: metallacarboranes as specific and potent inhibitors of HIV protease. Proc Natl Acad Sci USA (2005) vol. 102 (43) pp. 15394-9