HCO Classifier

Although the current bioinformatics methods distinguish between NOR and HCO enzymes, to date none is able to classify any enzyme according to its type. The exponential increase of available HCO and NOR sequences made this manual classification unfeasible.

This simple pipeline allows an automated classification of a fasta sequence by blasting the query against our HCO and NOR DB and classifying it as the best hit (1).

The precision and recall of the method are both of 99.8 % .

References

1. Altschul, S.F., et al., Gapped BLAST and PSI-BLAST: a new generation of protein database search programs, Nucleic Acids Res, 1997. 25(17), 3389-402.